National Cancer Institute at the National Institutes of Health


Importantly, atorvastatin also mediates a significant reduction in the phosphorylated forms of ERK1/2 and STAT3, and reduces HNSCC cell motility, invasion, proliferation, and colony formation. These in vitro results provide support for the suggestion that statin exposure/administration may potentially represent a therapeutic intervention for the treatment of HNSCC . Results demonstrated the potential of SMV to function as a radio-protective agent for salivary glands. The protective benefits of SMV were thought to be due to scavenging of radiation-induced free radicals, minimizing collagen deposition, and reducing/delaying the elevation of transforming growth factor β1 expression, which is induced by radiation. Therefore, it is suggested that statins may potentially represent a clinically useful treatment to alleviate the side effects of radiotherapy on salivary glands.

The typical dosing for pravastatin is 40 mg by mouth once a day. Dosing usually starts low, and can be increased depending on risk factors and side effects. Statins are cholesterol-lowering medications that help to lower “bad” cholesterol by blocking cholesterol production in the liver. Unfortunately, I have also lost a LOT of leg and arm muscle mass, but i don’t know if this was caused by this drug. I had to stop taking Lipitor due to muscle soreness and muscle loss.

Even if the medication is working, you may experience some unwanted side effects. When I tried to go back to swimming, i found there was so much pressure on my chest that I couldn’t get my breath. Yesterday, I began to feel normal for the first time in more than a year. I have alot of anger at the medical profession for not listening to patients when they report these side effects.

By improving cholesterol levels, this drug can help slow the development of heart disease. This drug should be used in combination with a healthy diet, weight loss, and exercise. “All patients starting therapy with Lipitor should be advised of the risk of myopathy and told to report promptly any unexplained muscle pain, tenderness, or weakness,” according franco’s barber to the drug label. Some Lipitor patients report various types of muscle injuries after taking the drug. Hepatic aminotransferase elevation is usually mild and does not require discontinuation of the statin. The requirement for routine monitoring of hepatic transaminases was removed from statin labeling by the US Food and Drug Administration in 2012.

Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. If you think you may have a medical emergency, immediately call your physician or dial 911. Pravastatin is a generic medication that is usually covered by Medicare and insurance plans. The average cash price of pravastatin is around $129.99 for a 30-day supply. A SingleCare savings card may be able to lower the cost of a pravastatin prescription to less than $15. Pravastatin and Lipitor can also increase HDL levels in the blood.

Taking pravastatin while pregnant could lead to birth defects. While the amount of pravastatin ingested by an infant from breastfeeding is low, patients breastfeeding should not take pravastatin due to potential effects on the infant’s lipid metabolism. Pravastatin, sold under the brand name Pravachol among others, is a statin medication, used for preventing cardiovascular disease in those at high risk and treating abnormal lipids. It should be used together with diet changes, exercise, and weight loss. Our analyses also help to address multiple concerns that have been raised about previous analyses of the effects of statins on muscle symptoms.


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